SGPP1

Across TCGA cell cohorts, SGPP1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SGPP1-associated genes across cancer lineages are DSG4, KRTAP10-10, and C6orf118. Each is linked with SGPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGPP1-to-partner and partner-to-SGPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSG4 grouped by SGPP1-low versus SGPP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGPP1→partner) and Y-score (partner→SGPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DSG4 →	+0.041	+5.269	<.001	<.001	3	2
OESOPHAGUS	KRTAP10-10 →	+0.020	+4.906	<.001	.006	3	1
LARGE_INTESTINE	C6orf118 →	+0.186	+3.793	<.001	.007	3	1
BLOOD_Leukemia	F9 →	+0.014	+4.969	<.001	.003	3	1
BLOOD_Leukemia	SYNPR →	+0.039	+4.409	<.001	.005	3	1
BLOOD_Leukemia	WFDC12 →	+0.349	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

DSG4 by SGPP1 expression — BLOOD_Leukemia

Explore this box plot interactively →