SGPL1

Across TCGA patient cohorts, SGPL1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,815 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SGPL1-associated genes across cancer lineages are SPARCL1, TNXB, and CEP55. Each is linked with SGPL1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SGPL1-to-partner and partner-to-SGPL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SGPL1 versus SPARCL1 in UCEC, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGPL1→partner) and Y-score (partner→SGPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPARCL1 →	-1.150	-0.533	.004	<.001	3	5
HNSC	TNXB →	-1.013	-0.424	<.001	<.001	3	5
LSCC	CEP55 →	+0.939	+0.314	<.001	<.001	3	5
LSCC	SUPV3L1 →	+0.512	+0.349	<.001	<.001	3	5
LSCC	CDK1 →	+0.951	+0.307	<.001	<.001	3	5
HNSC	MRPS16 →	+0.611	+0.256	.009	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,815 associations by consensus.

SGPL1 vs SPARCL1 — UCEC

Explore this scatter interactively →