SGPL1

Across TCGA patient cohorts, SGPL1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGPL1-associated genes across cancer lineages are ASNS, EGFR_pY1068, and eIF4E. Each is linked with SGPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGPL1-to-partner and partner-to-SGPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SGPL1-low versus SGPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGPL1→partner) and Y-score (partner→SGPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.580	+3.700	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.265	-2.415	.008	.003	3	1
UCEC	eIF4E →	+0.215	+2.415	.011	.003	2	2
UCEC	MEK1 →	+0.532	+3.087	<.001	<.001	3	1
UCEC	Notch1 →	+0.180	+2.009	.001	.017	3	1
UCEC	p62 Lck ligand →	+0.400	+3.087	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ASNS by SGPL1 expression — UCEC

Explore this box plot interactively →