SGPL1

Across TCGA cell cohorts, SGPL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,420 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SGPL1-associated GO terms across cancer lineages are Post-Golgi vesicle-mediated transport, Viral translational termination-reinitiation, and Cytosolic transport. Each is linked with SGPL1 in more than 11 cancer types. Because this analysis shows association rather than direction, both SGPL1-to-partner and partner-to-SGPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-Golgi vesicle-mediated transport grouped by SGPL1-low versus SGPL1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SGPL1→partner) and Y-score (partner→SGPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Post-Golgi vesicle-mediated transport →	+0.076	+1.198	<.001	<.001	3	12
LARGE_INTESTINE	Viral translational termination-reinitiation →	+0.090	+0.977	<.001	<.001	3	11
KIDNEY	Cytosolic transport →	+0.080	+0.874	.001	.008	3	11
OVARY	Regulation of protein localization to nucleus →	+0.101	+1.357	<.001	<.001	3	11
BLOOD_Lymphoma	Positive regulation of activin receptor signaling pathway →	-0.143	-0.527	<.001	.005	3	11
OVARY	Positive regulation of GTPase activity →	+0.054	+0.817	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,420 associations by consensus.

Post-Golgi vesicle-mediated transport by SGPL1 expression — LUNG_SCLC

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