SGO2

Across TCGA pan-cancer cohorts, SGO2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SGO2 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SGO2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SGO2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where SGO2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.972	0.610	.001	36	view →
HNSC	DFS	Median	III,IV	0.161	0.680	.016	24	view →
LUAD	OS	Median	III,IV	0.083	0.680	<.001	12	view →
LGG	DFS	Median	All	0.190	0.753	.002	3	view →
SARC	OS	Median	All	0.250	0.766	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SGO2–UCEC (DFS)

Open the UCEC breakdown →