SGO2

Across TCGA patient cohorts, SGO2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,224 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SGO2-associated genes across cancer lineages are RAD18, HELLS, and MCM8. Each is linked with SGO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SGO2-to-partner and partner-to-SGO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SGO2 versus RAD18 in BRCA, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGO2→partner) and Y-score (partner→SGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAD18 →	+0.825	+1.410	<.001	.002	3	3
LSCC	HELLS →	+1.152	+1.074	.002	.002	3	2
LSCC	MCM8 →	+0.959	+1.017	.007	.001	3	2
HNSC	ZNF670-ZNF695 →	+0.903	+1.188	.002	.001	2	3
HNSC	CENPO →	+0.968	+0.976	.002	.005	3	2
LSCC	SUV39H2 →	+1.031	+0.959	.009	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,224 associations by consensus.

SGO2 vs RAD18 — BRCA

Explore this scatter interactively →