SGO2

Across TCGA patient cohorts, SGO2 mutation is significantly associated with the RNA expression of many other genes, with 3,430 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGO2-associated genes across cancer lineages are RNA5SP57, RNU6-218P, and MRPS15P1. Each is linked with SGO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SGO2-to-partner and partner-to-SGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP57 grouped by SGO2-low versus SGO2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGO2→partner) and Y-score (partner→SGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP57 →	+0.370	+5.155	<.001	.002	3	3
UCEC	RNU6-218P →	+0.400	+1.467	<.001	.001	3	3
READ	MRPS15P1 →	+0.104	+4.827	<.001	.002	3	2
UCEC	NOL12 →	+0.285	+1.769	<.001	<.001	3	2
COAD	REXO1L8P →	+0.026	+5.142	<.001	.002	3	2
LUAD	RNU6-17P →	+0.224	+4.399	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,430 associations by consensus.

RNA5SP57 by SGO2 expression — LUAD

Explore this box plot interactively →