SGO2

Across TCGA cell cohorts, SGO2 mutation is significantly associated with the RNA expression of many other genes, with 141 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SGO2-associated genes across cancer lineages are OR10G2, CACNG3, and REG1B. Each is linked with SGO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGO2-to-partner and partner-to-SGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G2 grouped by SGO2-low versus SGO2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGO2→partner) and Y-score (partner→SGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10G2 →	+1.169	+3.551	<.001	.009	3	2
OESOPHAGUS	CACNG3 →	+0.030	+4.906	<.001	.006	3	1
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	1
LUNG_NSCLC_LUAD	TRIML1 →	+0.120	+4.371	<.001	.005	3	1
LARGE_INTESTINE	JOSD1 →	+0.557	+3.212	.006	.006	3	1
LARGE_INTESTINE	TBX18 →	+1.017	+3.385	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 141 associations by consensus.

OR10G2 by SGO2 expression — BLOOD_Leukemia

Explore this box plot interactively →