SGO1

Across TCGA patient cohorts, SGO1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGO1-associated genes across cancer lineages are PCNA, ATM, and A-Raf_pS299. Each is linked with SGO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGO1-to-partner and partner-to-SGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SGO1-low versus SGO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGO1→partner) and Y-score (partner→SGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.181	+3.169	.029	.018	3	2
UCEC	ATM →	-0.683	-2.087	<.001	.005	3	2
UCEC	A-Raf_pS299 →	-0.111	-2.321	.015	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-2.321	.002	.005	3	1
UCEC	JNK2 →	+0.199	+1.678	.009	.023	3	1
UCEC	Ku80 →	+0.245	+2.100	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PCNA by SGO1 expression — UCEC

Explore this box plot interactively →