SGO1

Across TCGA cell cohorts, SGO1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible SGO1-associated genes across cancer lineages are ZNF804B, MPC1L, and OR9I1. Each is linked with SGO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGO1-to-partner and partner-to-SGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF804B grouped by SGO1-low versus SGO1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGO1→partner) and Y-score (partner→SGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZNF804B →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	MPC1L →	+0.083	+5.087	<.001	.004	3	1
SKIN	OR9I1 →	+0.006	+6.022	<.001	.001	3	1
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
OVARY	IQCF2 →	+0.052	+5.196	<.001	.005	3	1
LARGE_INTESTINE	SPINK9 →	+0.329	+3.793	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ZNF804B by SGO1 expression — URINARY_TRACT

Explore this box plot interactively →