SGMS2

Across TCGA patient cohorts, SGMS2 mutation is significantly associated with the RNA expression of many other genes, with 2,836 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGMS2-associated genes across cancer lineages are MIR3661, RNY3P2, and KRTAP20-3. Each is linked with SGMS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGMS2-to-partner and partner-to-SGMS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3661 grouped by SGMS2-low versus SGMS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGMS2→partner) and Y-score (partner→SGMS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3661 →	+0.762	+1.814	<.001	.003	3	2
BLCA	RNY3P2 →	+0.396	+4.859	<.001	.004	3	2
UCEC	KRTAP20-3 →	+0.055	+3.812	<.001	.008	3	2
UCEC	MIR615 →	+0.340	+2.717	<.001	<.001	3	2
UCEC	NFYBP1 →	+0.198	+2.242	<.001	<.001	3	2
UCEC	RNA5SP198 →	+0.329	+2.534	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,836 associations by consensus.

MIR3661 by SGMS2 expression — UCEC

Explore this box plot interactively →