SGMS2

Across TCGA patient cohorts, SGMS2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGMS2-associated genes across cancer lineages are eIF4E, ACC1, and Heregulin. Each is linked with SGMS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGMS2-to-partner and partner-to-SGMS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SGMS2-low versus SGMS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGMS2→partner) and Y-score (partner→SGMS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.207	+3.335	.017	.005	3	1
UCEC	ACC1 →	+0.337	+2.820	.024	.035	3	1
UCEC	Heregulin →	-0.118	-2.115	.020	.017	3	1
UCEC	MEK1 →	+0.400	+2.321	.008	.006	3	1
UCEC	PDCD4 →	-0.529	-2.449	.006	.019	3	1
UCEC	PDK1_pS241 →	+0.195	+2.584	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4E by SGMS2 expression — UCEC

Explore this box plot interactively →