SGMS2

Across TCGA cell cohorts, SGMS2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SGMS2-associated genes across cancer lineages are ASB17, OR52H1, and OR56A4. Each is linked with SGMS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SGMS2-to-partner and partner-to-SGMS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by SGMS2-low versus SGMS2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGMS2→partner) and Y-score (partner→SGMS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	3
LARGE_INTESTINE	OR52H1 →	+0.025	+3.347	<.001	.005	3	2
SOFT_TISSUE	OR56A4 →	+0.016	+5.977	<.001	.001	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PSMB11 →	+0.025	+3.878	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ASB17 by SGMS2 expression — OVARY

Explore this box plot interactively →