Across TCGA pan-cancer cohorts, SGMS1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SGMS1 data layer compared with 19 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SGMS1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SGMS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, OV, and ACC are the cancer types where SGMS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.617	.005	32	view →
OV	OS	Median	II,III,IV	0.282	0.845	<.001	18	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
SKCM	OS	Median	II,III,IV	0.987	0.821	.019	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SGMS1 tumor-vs-normal RNA expression · all SGMS1 data types