Across TCGA pan-cancer cohorts, SGMS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SGMS1 data layer compared with 19 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SGMS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SGMS1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where SGMS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.221	0.864	.009	15	view →
CCRCC	DFS	Median	III,IV	0.801	0.193	.003	11	view →
HNSC	OS	Quartile	All	0.867	0.489	.004	10	view →
PDAC	DFS	Median	All	0.440	1.000	.024	6	view →
LSCC	OS	Median	II,III,IV	1.000	0.810	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SGMS1 tumor-vs-normal RNA expression · all SGMS1 data types