Across TCGA patient cohorts, SGMS1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGMS1-associated genes across cancer lineages are ASNS, Notch1, and Rad50. Each is linked with SGMS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SGMS1-to-partner and partner-to-SGMS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGMS1→partner) and Y-score (partner→SGMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.448	+2.906	.001	.001	3	4
UCEC	Notch1 →	+0.127	+2.183	.018	.033	3	2
UCEC	Rad50 →	-0.244	-2.087	.008	.005	3	2
UCEC	Tuberin_pT1462 →	+0.263	+1.678	.003	.023	3	2
UCEC	C-Raf →	+0.172	+1.678	.001	.023	3	2
SKCM	JNK_pT183_Y185 →	-0.129	-2.169	.011	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

SGMS1 survival (RNA) · tumor vs normal (RNA) · all SGMS1 data types