SGK3

Across TCGA pan-cancer cohorts, SGK3 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SGK3’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SGK3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SGK3 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

CCRCC and HNSC are the cancer types where SGK3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SGK3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−0.915	<.001	8	view →
HNSC	All	All	+1.817	.022	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

SGK3–CCRCC

Open the CCRCC breakdown →