SGK3

Across TCGA patient cohorts, SGK3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGK3-associated genes across cancer lineages are ASNS, eIF4E, and FoxM1. Each is linked with SGK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGK3-to-partner and partner-to-SGK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SGK3-low versus SGK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGK3→partner) and Y-score (partner→SGK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.576	+2.906	<.001	.001	3	2
UCEC	eIF4E →	+0.256	+3.321	.001	<.001	3	1
UCEC	FoxM1 →	+0.239	+1.415	.013	.046	3	1
UCEC	GATA6 →	-0.154	-1.577	.011	.036	3	1
UCEC	JNK2 →	+0.234	+2.169	.001	.003	3	1
UCEC	MEK1 →	+0.420	+3.807	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ASNS by SGK3 expression — UCEC

Explore this box plot interactively →