SGK3

Across TCGA cell cohorts, SGK3 mutation is significantly associated with the RNA expression of many other genes, with 514 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SGK3-associated genes across cancer lineages are CHRNB3, ODF1, and GH2. Each is linked with SGK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGK3-to-partner and partner-to-SGK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNB3 grouped by SGK3-low versus SGK3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGK3→partner) and Y-score (partner→SGK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CHRNB3 →	+0.011	+4.467	<.001	.004	3	1
SKIN	ODF1 →	+0.020	+5.022	<.001	.002	3	1
LUNG_NSCLC_LUAD	GH2 →	+0.054	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	GP9 →	+0.019	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR11A1 →	+0.033	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	PIRT →	+0.005	+4.189	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 514 associations by consensus.

CHRNB3 by SGK3 expression — SKIN

Explore this box plot interactively →