SGK2

Across TCGA patient cohorts, SGK2 mutation is significantly associated with the RNA expression of many other genes, with 1,857 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGK2-associated genes across cancer lineages are STARD7-AS1, KIF9-AS1, and RN7SL354P. Each is linked with SGK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SGK2-to-partner and partner-to-SGK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STARD7-AS1 grouped by SGK2-low versus SGK2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGK2→partner) and Y-score (partner→SGK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STARD7-AS1 →	+0.379	+3.207	.001	.009	3	3
UCEC	KIF9-AS1 →	+0.368	+2.447	.001	.001	3	3
UCEC	RN7SL354P →	+0.270	+1.914	<.001	.005	3	3
SKCM	SPATA5L1 →	+0.467	+1.925	.003	.009	3	2
UCEC	LRRC20 →	+0.602	+2.592	.006	.006	3	2
SKCM	ZWILCH →	+0.598	+1.925	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,857 associations by consensus.

STARD7-AS1 by SGK2 expression — SKCM

Explore this box plot interactively →