SGK2

Across TCGA patient cohorts, SGK2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGK2-associated genes across cancer lineages are Cyclin-B1, Di-Ras3, and p90 RSK_pT359_S363. Each is linked with SGK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGK2-to-partner and partner-to-SGK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SGK2-low versus SGK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGK2→partner) and Y-score (partner→SGK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.800	+3.321	.002	.009	3	2
UCEC	Di-Ras3 →	-0.202	-2.584	.003	.011	3	2
SKCM	p90 RSK_pT359_S363 →	+0.189	+2.321	.026	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.142	-2.312	.015	.034	3	1
UCEC	HSP70 →	-0.495	-3.160	.008	.019	3	1
UCEC	INPP4B →	-0.352	-2.321	.019	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Cyclin-B1 by SGK2 expression — UCEC

Explore this box plot interactively →