SGK2

Across TCGA cell cohorts, SGK2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible SGK2-associated genes across cancer lineages are LYZL2, ST8SIA3, and SLURP1. Each is linked with SGK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGK2-to-partner and partner-to-SGK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL2 grouped by SGK2-low versus SGK2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGK2→partner) and Y-score (partner→SGK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LYZL2 →	+0.062	+3.432	<.001	.008	3	2
BLOOD_Myeloma	ST8SIA3 →	+0.053	+4.807	<.001	.006	3	1
STOMACH	SLURP1 →	+0.385	+3.632	<.001	.009	3	1
STOMACH	TRARG1 →	+0.018	+3.830	<.001	.005	3	1
STOMACH	AJAP1 →	+0.153	+4.222	<.001	.001	3	1
STOMACH	DAZ2 →	+0.989	+3.432	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

LYZL2 by SGK2 expression — STOMACH

Explore this box plot interactively →