SGCG

Across TCGA patient cohorts, SGCG protein abundance is significantly associated with the RNA expression of many other genes, with 14,019 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SGCG-associated genes across cancer lineages are CLIC5, AOC3, and ATP1A2. Each is linked with SGCG in more than 2 cancer types. Because this analysis shows association rather than direction, both SGCG-to-partner and partner-to-SGCG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SGCG versus CLIC5 in HNSC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCG→partner) and Y-score (partner→SGCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLIC5 →	+0.894	+1.093	<.001	.002	3	3
BRCA	AOC3 →	+2.211	+0.958	.006	.008	3	3
HNSC	ATP1A2 →	+2.093	+1.402	<.001	<.001	3	3
HNSC	CTSG →	+1.119	+0.916	<.001	<.001	3	2
HNSC	MYOM1 →	+1.552	+1.278	<.001	<.001	3	2
BRCA	ASPA →	+1.440	+0.958	.003	.008	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,019 associations by consensus.

SGCG vs CLIC5 — HNSC

Explore this scatter interactively →