SGCG

Across TCGA patient cohorts, SGCG mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGCG-associated genes across cancer lineages are EGFR, ACC1, and JNK_pT183_Y185. Each is linked with SGCG in more than 1 cancer types. Because this analysis shows association rather than direction, both SGCG-to-partner and partner-to-SGCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by SGCG-low versus SGCG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCG→partner) and Y-score (partner→SGCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.243	-2.584	<.001	.010	3	1
UCEC	ACC1 →	+0.296	+2.321	.049	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.211	-2.308	.002	.006	3	1
UCEC	Ku80 →	+0.283	+1.820	.003	.016	3	1
UCEC	MEK1 →	+0.418	+2.459	.005	.019	3	1
UCEC	Notch1 →	+0.258	+3.598	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR by SGCG expression — UCEC

Explore this box plot interactively →