SGCD

Across TCGA patient cohorts, SGCD mutation is significantly associated with the RNA expression of many other genes, with 4,701 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGCD-associated genes across cancer lineages are CCT7, SMYD5, and MIR6078. Each is linked with SGCD in more than 3 cancer types. Because this analysis shows association rather than direction, both SGCD-to-partner and partner-to-SGCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT7 grouped by SGCD-low versus SGCD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCD→partner) and Y-score (partner→SGCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCT7 →	+0.304	+1.857	.008	<.001	3	3
UCEC	SMYD5 →	+0.309	+2.115	<.001	<.001	3	3
BRCA	MIR6078 →	+0.348	+6.016	<.001	.002	3	2
CESC	NF1P10 →	+0.085	+3.984	.001	.009	3	2
SKCM	RNA5SP468 →	+0.360	+4.979	<.001	.009	3	2
HNSC	RNA5SP110 →	+0.702	+5.111	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,701 associations by consensus.

CCT7 by SGCD expression — UCEC

Explore this box plot interactively →