SGCD

Across TCGA patient cohorts, SGCD mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGCD-associated genes across cancer lineages are FoxM1, Annexin_VII, and TFRC. Each is linked with SGCD in more than 1 cancer types. Because this analysis shows association rather than direction, both SGCD-to-partner and partner-to-SGCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SGCD-low versus SGCD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCD→partner) and Y-score (partner→SGCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.252	+2.459	.004	<.001	3	2
UCEC	Annexin_VII →	-0.102	-1.440	.034	.024	3	2
UCEC	TFRC →	+0.545	+2.700	.003	.005	3	2
UCEC	C-Raf →	+0.130	+2.321	.009	.005	3	2
UCEC	eEF2 →	+0.323	+1.736	.009	.007	3	1
UCEC	eIF4E →	+0.159	+1.440	.029	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

FoxM1 by SGCD expression — UCEC

Explore this box plot interactively →