SGCD

Across TCGA cell cohorts, SGCD mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SGCD-associated genes across cancer lineages are AVP, ODF1, and PDCL2. Each is linked with SGCD in more than 1 cancer types. Because this analysis shows association rather than direction, both SGCD-to-partner and partner-to-SGCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by SGCD-low versus SGCD-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGCD→partner) and Y-score (partner→SGCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.031	+4.794	<.001	<.001	3	1
SKIN	ODF1 →	+0.020	+5.022	<.001	.002	3	1
SKIN	PDCL2 →	+0.488	+4.930	<.001	.001	3	1
SKIN	SPINK9 →	+0.048	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	NTSR1 →	+2.092	+3.343	<.001	.005	3	1
LUNG_NSCLC_LUAD	GDA →	+2.500	+3.206	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

AVP by SGCD expression — BLOOD_Lymphoma

Explore this box plot interactively →