SFXN5

Across TCGA pan-cancer cohorts, SFXN5 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SFXN5 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SFXN5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SFXN5 expression acts as an unfavorable survival marker.

ESCA and UCEC are the cancer types where SFXN5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	II,III,IV	0.080	0.523	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SFXN5–ESCA (DFS)

Open the ESCA breakdown →