SFXN5

Across TCGA patient cohorts, SFXN5 mutation is significantly associated with the RNA expression of many other genes, with 2,000 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFXN5-associated genes across cancer lineages are RNA5SP412, RNA5SP422, and RNA5SP414. Each is linked with SFXN5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SFXN5-to-partner and partner-to-SFXN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by SFXN5-low versus SFXN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFXN5→partner) and Y-score (partner→SFXN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.429	+1.967	.001	.002	3	4
UCEC	RNA5SP422 →	+0.637	+1.671	<.001	.009	3	3
UCEC	RNA5SP414 →	+0.405	+1.975	.001	.004	3	3
BLCA	OR8B8 →	+0.030	+5.899	.009	.002	3	2
UCEC	LINC02167 →	+2.500	+2.664	<.001	<.001	3	2
UCEC	TRAJ11 →	+0.433	+1.813	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,000 associations by consensus.

RNA5SP412 by SFXN5 expression — UCEC

Explore this box plot interactively →