SFXN5

Across TCGA cell cohorts, SFXN5 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SFXN5-associated genes across cancer lineages are KRTAP5-3, OR10A4, and OR4F21. Each is linked with SFXN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFXN5-to-partner and partner-to-SFXN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-3 grouped by SFXN5-low versus SFXN5-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFXN5→partner) and Y-score (partner→SFXN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KRTAP5-3 →	+0.021	+5.000	.004	.006	3	1
LARGE_INTESTINE	OR10A4 →	+0.045	+2.938	.007	.007	3	1
LARGE_INTESTINE	OR4F21 →	+0.168	+2.878	<.001	.009	3	1
LARGE_INTESTINE	TMEM210 →	+0.089	+3.714	.004	.004	3	1
LARGE_INTESTINE	CTXND2 →	+0.036	+3.832	<.001	<.001	3	1
LARGE_INTESTINE	PIK3R6 →	+0.035	+3.409	.002	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

KRTAP5-3 by SFXN5 expression — PANCREAS

Explore this box plot interactively →