SFXN3

Across TCGA patient cohorts, SFXN3 mutation is significantly associated with the RNA expression of many other genes, with 980 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFXN3-associated genes across cancer lineages are TRIM48, HMGN1P20, and GLUD1P4. Each is linked with SFXN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFXN3-to-partner and partner-to-SFXN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM48 grouped by SFXN3-low versus SFXN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFXN3→partner) and Y-score (partner→SFXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM48 →	+0.208	+1.903	.007	.004	3	2
UCEC	HMGN1P20 →	+0.138	+2.167	<.001	.004	3	2
BLCA	GLUD1P4 →	+0.101	+4.788	<.001	.006	3	2
SKCM	DIS3L2P1 →	+0.044	+4.199	<.001	.009	3	2
SKCM	RNU7-90P →	+0.343	+4.328	<.001	.007	3	2
SKCM	SUGT1P4 →	+0.260	+4.328	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 980 associations by consensus.

TRIM48 by SFXN3 expression — UCEC

Explore this box plot interactively →