SFXN3

Across TCGA cell cohorts, SFXN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,255 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SFXN3-associated GO terms across cancer lineages are Serine import into mitochondrion, Regulation of cell-matrix adhesion, and Actin filament capping. Each is linked with SFXN3 in more than 15 cancer types. Because this analysis shows association rather than direction, both SFXN3-to-partner and partner-to-SFXN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Serine import into mitochondrion grouped by SFXN3-low versus SFXN3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SFXN3→partner) and Y-score (partner→SFXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Serine import into mitochondrion →	+0.187	+1.653	<.001	<.001	3	16
BONE	Regulation of cell-matrix adhesion →	+0.150	+1.432	<.001	<.001	3	15
LIVER	Actin filament capping →	+0.239	+2.521	.002	.005	3	15
BONE	Regulation of focal adhesion assembly →	+0.167	+1.386	<.001	<.001	3	14
BONE	Regulation of cell-substrate junction assembly →	+0.167	+1.386	<.001	<.001	3	14
BONE	Regulation of cell-substrate adhesion →	+0.137	+1.393	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,255 associations by consensus.

Serine import into mitochondrion by SFXN3 expression — LUNG_SCLC

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