SFXN2

Across TCGA patient cohorts, SFXN2 mutation is significantly associated with the RNA expression of many other genes, with 373 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFXN2-associated genes across cancer lineages are SPACA1, RPL7L1P4, and NDUFB4P9. Each is linked with SFXN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFXN2-to-partner and partner-to-SFXN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPACA1 grouped by SFXN2-low versus SFXN2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFXN2→partner) and Y-score (partner→SFXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SPACA1 →	+0.109	+5.418	<.001	.005	3	2
SKCM	RPL7L1P4 →	+0.060	+3.953	.001	.005	3	2
SKCM	NDUFB4P9 →	+0.070	+4.385	<.001	.008	3	2
CESC	NF1P7 →	+0.034	+5.812	.002	.003	3	2
UCEC	SSXP4 →	+0.050	+4.148	.007	.006	3	2
UCEC	RFKP1 →	+0.139	+3.242	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 373 associations by consensus.

SPACA1 by SFXN2 expression — CESC

Explore this box plot interactively →