SFXN2

Across TCGA patient cohorts, SFXN2 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFXN2-associated genes across cancer lineages are p62 Lck ligand, p27_pT198, and S6_pS240_S244. Each is linked with SFXN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFXN2-to-partner and partner-to-SFXN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SFXN2-low versus SFXN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFXN2→partner) and Y-score (partner→SFXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.358	+3.321	.035	.010	3	1
UCEC	p27_pT198 →	+0.135	+3.321	.016	.010	1	1
UCEC	S6_pS240_S244 →	+0.553	+3.321	.009	.010	1	1
UCEC	beta-Catenin →	+0.576	+3.321	.030	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

p62 Lck ligand by SFXN2 expression — UCEC

Explore this box plot interactively →