SFXN1

Across TCGA pan-cancer cohorts, SFXN1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SFXN1 data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SFXN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SFXN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

PDAC, HNSC, and GBM are the cancer types where SFXN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.583	0.973	<.001	49	view →
HNSC	DFS	Tertile	IV	0.938	0.582	.002	42	view →
GBM	DFS	Quartile	All	0.889	0.589	.004	13	view →
LSCC	DFS	Median	II,III,IV	1.000	0.832	.004	9	view →
UCEC	OS	Median	III,IV	1.000	0.557	.047	8	view →
CCRCC	DFS	Quartile	All	0.606	0.885	.040	3	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SFXN1–PDAC (DFS)

Open the PDAC breakdown →