SFXN1

Across TCGA patient cohorts, SFXN1 mutation is significantly associated with the RNA expression of many other genes, with 499 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFXN1-associated genes across cancer lineages are OSBPL9P1, RN7SL837P, and RNU6-172P. Each is linked with SFXN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFXN1-to-partner and partner-to-SFXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OSBPL9P1 grouped by SFXN1-low versus SFXN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFXN1→partner) and Y-score (partner→SFXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OSBPL9P1 →	+0.067	+5.516	.009	.004	3	2
SKCM	RN7SL837P →	+0.101	+4.671	<.001	.004	3	2
SKCM	RNU6-172P →	+0.456	+3.622	<.001	.005	3	2
UCEC	RNY1P1 →	+0.182	+3.013	<.001	.007	3	2
UCEC	LINC01810 →	+0.072	+3.400	.003	.003	3	2
UCEC	HMGB3P3 →	+0.181	+2.021	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 499 associations by consensus.

OSBPL9P1 by SFXN1 expression — COAD

Explore this box plot interactively →