SFXN1

Across TCGA patient cohorts, SFXN1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFXN1-associated genes across cancer lineages are EGFR_pY1068, ACC_pS79, and TIGAR. Each is linked with SFXN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFXN1-to-partner and partner-to-SFXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SFXN1-low versus SFXN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFXN1→partner) and Y-score (partner→SFXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.301	-2.000	.007	.032	3	1
UCEC	ACC_pS79 →	+0.322	+2.000	.039	.032	3	1
UCEC	TIGAR →	+0.215	+3.321	.001	.010	3	1
UCEC	Tuberin_pT1462 →	+0.270	+2.179	.009	.034	3	1
UCEC	Tuberin →	+0.375	+3.169	.002	.018	3	1
UCEC	Caspase-7-cleavedD198 →	+0.765	+2.341	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1068 by SFXN1 expression — UCEC

Explore this box plot interactively →