SFXN1

Across TCGA cell cohorts, SFXN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,093 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SFXN1-associated GO terms across cancer lineages are DNA replication initiation, Positive regulation of G2/M transition of mitotic cell cycle, and Regulation of cell cycle G2/M phase transition. Each is linked with SFXN1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SFXN1-to-partner and partner-to-SFXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by SFXN1-low versus SFXN1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SFXN1→partner) and Y-score (partner→SFXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DNA replication initiation →	+0.142	+1.061	.001	.007	2	17
LUNG_NSCLC_LUSC	Positive regulation of G2/M transition of mitotic cell cycle →	+0.115	+1.370	.001	.001	2	16
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle G2/M phase transition →	+0.067	+1.398	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cytokinesis →	+0.194	+1.701	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Positive regulation of cell cycle →	+0.063	+1.374	<.001	<.001	3	15
LIVER	Positive regulation of mitotic cell cycle →	+0.078	+1.089	.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,093 associations by consensus.

DNA replication initiation by SFXN1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →