SFTPD

Across TCGA patient cohorts, SFTPD mutation is significantly associated with the RNA expression of many other genes, with 1,862 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFTPD-associated genes across cancer lineages are RNU6-13P, ZNHIT3, and FAM219B. Each is linked with SFTPD in more than 2 cancer types. Because this analysis shows association rather than direction, both SFTPD-to-partner and partner-to-SFTPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-13P grouped by SFTPD-low versus SFTPD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFTPD→partner) and Y-score (partner→SFTPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-13P →	+0.218	+1.969	.004	.008	3	3
UCEC	ZNHIT3 →	+0.426	+3.343	.002	<.001	3	2
UCEC	FAM219B →	+0.517	+2.711	<.001	.003	3	2
UCEC	CCDC43 →	+0.537	+3.354	<.001	<.001	3	2
UCEC	SLC26A11 →	+0.428	+3.191	.006	.009	3	2
UCEC	SKA2 →	+0.589	+4.024	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,862 associations by consensus.

RNU6-13P by SFTPD expression — UCEC

Explore this box plot interactively →