SFTPD

Across TCGA patient cohorts, SFTPD mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFTPD-associated genes across cancer lineages are eEF2, ATM, and Caspase-8. Each is linked with SFTPD in more than 1 cancer types. Because this analysis shows association rather than direction, both SFTPD-to-partner and partner-to-SFTPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SFTPD-low versus SFTPD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFTPD→partner) and Y-score (partner→SFTPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.402	+2.321	.005	.033	3	2
UCEC	ATM →	-0.716	-3.087	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.244	-2.558	.015	.010	3	2
UCEC	EGFR_pY1068 →	-0.239	-2.415	.018	.003	3	1
UCEC	eIF4E →	+0.212	+3.087	.012	<.001	3	1
UCEC	eIF4G →	+0.379	+3.169	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eEF2 by SFTPD expression — UCEC

Explore this box plot interactively →