SFTPD

Across TCGA cell cohorts, SFTPD mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SFTPD-associated genes across cancer lineages are H2BW2, DMRTC2, and CYLC2. Each is linked with SFTPD in more than 1 cancer types. Because this analysis shows association rather than direction, both SFTPD-to-partner and partner-to-SFTPD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW2 grouped by SFTPD-low versus SFTPD-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFTPD→partner) and Y-score (partner→SFTPD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	H2BW2 →	+0.033	+4.472	.002	.004	3	1
CNS	DMRTC2 →	+0.053	+4.321	<.001	.009	3	1
CNS	CYLC2 →	+0.012	+4.321	<.001	.009	3	1
CNS	PROP1 →	+0.024	+4.643	<.001	.003	3	1
CNS	KRTAP11-1 →	+0.019	+4.754	<.001	.005	3	1
CNS	NANOGNB →	+0.033	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

H2BW2 by SFTPD expression — CNS

Explore this box plot interactively →