SFTPB

Across TCGA patient cohorts, SFTPB mutation is significantly associated with the RNA expression of many other genes, with 489 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFTPB-associated genes across cancer lineages are DNM1P24, RN7SL185P, and PKN3. Each is linked with SFTPB in more than 1 cancer types. Because this analysis shows association rather than direction, both SFTPB-to-partner and partner-to-SFTPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNM1P24 grouped by SFTPB-low versus SFTPB-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFTPB→partner) and Y-score (partner→SFTPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DNM1P24 →	+0.094	+7.954	<.001	.008	3	2
HNSC	RN7SL185P →	+0.134	+7.954	<.001	.008	3	2
UCEC	PKN3 →	+0.633	+2.818	.004	.001	3	2
UCEC	ACOT7 →	+0.658	+3.337	.009	.005	3	2
UCEC	MYO9B →	+0.434	+2.828	.006	.001	3	2
UCEC	TTC24 →	+0.233	+3.392	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 489 associations by consensus.

DNM1P24 by SFTPB expression — HNSC

Explore this box plot interactively →