SFTPB

Across TCGA patient cohorts, SFTPB mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFTPB-associated genes across cancer lineages are eEF2, eIF4E, and Cyclin-E1. Each is linked with SFTPB in more than 2 cancer types. Because this analysis shows association rather than direction, both SFTPB-to-partner and partner-to-SFTPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SFTPB-low versus SFTPB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFTPB→partner) and Y-score (partner→SFTPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.506	+2.999	.001	.035	3	2
COAD	eIF4E →	+0.263	+2.832	.007	.035	3	2
UCEC	Cyclin-E1 →	+0.469	+2.000	.016	.032	3	2
UCEC	EGFR_pY1068 →	-0.355	-2.584	.001	.010	3	2
COAD	Src_pY416 →	+0.420	+2.815	.005	.036	3	1
COAD	Chk1 →	+0.312	+2.815	.011	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eEF2 by SFTPB expression — UCEC

Explore this box plot interactively →