SFTPB

Across TCGA cell cohorts, SFTPB mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SFTPB-associated genes across cancer lineages are IQCF2, LCE2C, and ADAM2. Each is linked with SFTPB in more than 1 cancer types. Because this analysis shows association rather than direction, both SFTPB-to-partner and partner-to-SFTPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF2 grouped by SFTPB-low versus SFTPB-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFTPB→partner) and Y-score (partner→SFTPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IQCF2 →	+0.052	+5.196	<.001	.005	3	1
OVARY	LCE2C →	+0.073	+5.807	<.001	.001	3	1
BLOOD_Leukemia	ADAM2 →	+0.077	+4.539	.008	.007	3	1
BLOOD_Leukemia	PAX4 →	+0.014	+4.276	.001	.007	3	1
BLOOD_Leukemia	LCN9 →	+1.066	+4.539	<.001	.007	3	1
BLOOD_Leukemia	MCHR2 →	+0.034	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

IQCF2 by SFTPB expression — OVARY

Explore this box plot interactively →