Across TCGA patient cohorts, SFTA3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFTA3-associated genes across cancer lineages are EGFR_pY1068, Gab2, and MEK1. Each is linked with SFTA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFTA3-to-partner and partner-to-SFTA3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFTA3→partner) and Y-score (partner→SFTA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.342	-3.321	.006	.010	3	1
UCEC	Gab2 →	+0.448	+2.321	.012	.035	3	1
UCEC	MEK1 →	+0.378	+2.321	.040	.035	3	1
UCEC	Notch1 →	+0.233	+2.820	<.001	.035	3	1
UCEC	PCNA →	+0.230	+3.000	.033	.036	3	1
UCEC	Shc_pY317 →	-0.214	-3.459	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

SFTA3 survival (RNA) · tumor vs normal (RNA) · all SFTA3 data types