Across TCGA patient cohorts, SFT2D2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFT2D2-associated genes across cancer lineages are C-Raf, 14-3-3_beta, and eEF2. Each is linked with SFT2D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFT2D2-to-partner and partner-to-SFT2D2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFT2D2→partner) and Y-score (partner→SFT2D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.149	+1.362	.003	.037	3	2
UCEC	14-3-3_beta →	-0.089	-2.558	.011	.010	3	1
UCEC	eEF2 →	+0.254	+1.874	.044	.049	3	1
UCEC	EGFR_pY1068 →	-0.240	-1.662	.006	.011	3	1
UCEC	A-Raf_pS299 →	-0.141	-3.321	<.001	.009	3	1
UCEC	FoxM1 →	+0.211	+1.662	.020	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

SFT2D2 survival (RNA) · tumor vs normal (RNA) · all SFT2D2 data types