SFSWAP

Across TCGA pan-cancer cohorts, SFSWAP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SFSWAP data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SFSWAP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SFSWAP expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where SFSWAP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.698	0.879	.004	37	view →
LSCC	DFS	Median	II,III,IV	0.850	0.546	.012	22	view →
LUAD	DFS	Median	All	0.983	0.855	.001	15	view →
CCRCC	DFS	Quartile	All	0.886	1.000	.012	9	view →
UCEC	DFS	Median	III,IV	0.904	0.445	.037	4	view →
PDAC	DFS	Quartile	All	0.688	0.880	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SFSWAP–HNSC (DFS)

Open the HNSC breakdown →