SFSWAP

Across TCGA patient cohorts, SFSWAP mutation is significantly associated with the RNA expression of many other genes, with 3,949 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFSWAP-associated genes across cancer lineages are PSMB6, SNRPD3, and TOMM22. Each is linked with SFSWAP in more than 3 cancer types. Because this analysis shows association rather than direction, both SFSWAP-to-partner and partner-to-SFSWAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMB6 grouped by SFSWAP-low versus SFSWAP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFSWAP→partner) and Y-score (partner→SFSWAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSMB6 →	+0.637	+3.013	<.001	<.001	3	4
COAD	SNRPD3 →	+0.285	+3.472	.006	.002	3	3
UCEC	TOMM22 →	+0.360	+1.895	<.001	<.001	3	3
UCEC	SLC25A17 →	+0.278	+1.885	.002	<.001	3	3
UCEC	PHF5A →	+0.491	+2.584	<.001	<.001	3	3
UCEC	CINP →	+0.279	+2.906	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,949 associations by consensus.

PSMB6 by SFSWAP expression — COAD

Explore this box plot interactively →