SFSWAP

Across TCGA patient cohorts, SFSWAP mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFSWAP-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Met_pY1235, and EGFR_pY1068. Each is linked with SFSWAP in more than 3 cancer types. Because this analysis shows association rather than direction, both SFSWAP-to-partner and partner-to-SFSWAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SFSWAP-low versus SFSWAP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFSWAP→partner) and Y-score (partner→SFSWAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.423	+2.601	<.001	.005	3	4
UCEC	c-Met_pY1235 →	+0.062	+1.161	.005	.032	3	3
COAD	EGFR_pY1068 →	-0.381	-2.459	.002	.017	3	2
COAD	INPP4B →	-0.458	-2.898	.001	.001	3	2
UCEC	MEK1 →	+0.402	+2.273	<.001	<.001	3	2
COAD	RAD51 →	+0.214	+2.230	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by SFSWAP expression — COAD

Explore this box plot interactively →