SFSWAP

Across TCGA cell cohorts, SFSWAP mutation is significantly associated with the RNA expression of many other genes, with 498 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SFSWAP-associated genes across cancer lineages are CST5, KDSR, and RBMXL3. Each is linked with SFSWAP in more than 1 cancer types. Because this analysis shows association rather than direction, both SFSWAP-to-partner and partner-to-SFSWAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST5 grouped by SFSWAP-low versus SFSWAP-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFSWAP→partner) and Y-score (partner→SFSWAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CST5 →	+0.130	+4.981	<.001	.008	3	2
LARGE_INTESTINE	KDSR →	+0.797	+2.502	<.001	.005	3	2
BLOOD_Myeloma	RBMXL3 →	+0.012	+4.754	<.001	<.001	3	1
BLOOD_Myeloma	FGF4 →	+0.012	+4.285	<.001	.003	3	1
CNS	OR4X2 →	+0.041	+4.981	<.001	.008	3	1
STOMACH	IMPDH1 →	-1.101	-3.169	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 498 associations by consensus.

CST5 by SFSWAP expression — CNS

Explore this box plot interactively →